Should you haveany questions, please contact Sujatha Ramakrishna, Principal Scientific Liaison (301-816-8349 or sxr@usp.org). Atorvastatin is marketed as its calcium salt in crystalline trihydrate. Stars This entity has been manually annotated by … Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. It belongs to the product categories of Active Pharmaceutical Ingredients; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Atorvastatin. : 265989-46-6 . The Revision Bulletin will be incorporated in USP 42–NF 37. Compare Products: Select up to 4 products. Ca; C 66 H 68 CaF 2_ sN 4 O 10 MW : No. 1907/2006 as amended by (EC) No. Three atorvastatin-loaded formulations (FA1-FA3) were prepared by using varying polymer ratios of 1:1, 1:3, 1:5, and other excipients like starch, talc, and lactose. Crystal structure of atorvastatin calcium trihydrate Form I (Lipitor ® ), (C 33 H 34 FN 2 O 5 ) 2 Ca(H 2 O) 3. Adjust dosage at intervals of ≥4 weeks until the desired effect on lipoprotein concentrations is observed or a daily dosage of 20 mg is reached. It can raise triglyceride levels and may increase your risk of liver damage. The empirical formula of atorvastatin calcium is(C 33 H 34 FN 2 O 5)2Ca•3H 2 O and its molecular weight is 1209.42. Chemical structure of atorvastatin calcium (ATC). Atorvastatin (calcium salt) SAFETY DATA SHEET Supersedes Revision: 08/02/2018 according to Regulation (EC) No. ACT crystallizes in space group P1 (#1) with a=5.44731(4), b=9.88858(16), c=29.5925(10) Å, α=95.859(3), β=94.211(1), γ=105.2790(1)°, V=1521.277(10) Å3, and Z=1. 1. April 2020 Therefore, atorvastatin given on alternate days may be reasonable and cost effective, particularly in hypercholesterolemia patients. Atorvastatin calcium tablet is an HMG-CoA reductase inhibitor indicated as an adjunct therapy to diet to: Reduce the risk of MI, stroke, revascularization procedures, and angina in adult patients without CHD, but with multiple risk factors . Minimize drinking alcohol. CAS PubMed Google Scholar 15. It is therefore important to know the dose-related magnitude of effect of atorvastatin on blood lipids. Atorvastatin was marketed as its calcium salt (2:1) in crystalline trihydrate designated Form I under the brand ... which a solvent(s) “is coordinated in or accommodated by the crystal structure” [GRI06]. â Correspondence: Dr. J. Ulrich (joachim.ulrich@iw.uni-halle.de), Zentrum für Ingenieurwissenschaften, Verfahrenstechnik/TVT, MartinLuther-Universität Halle-Wittenberg, D-06099 Halle, Germany. 1 65. The crystal structure of atorvastatin calcium ethylene glycol solvate suggests atorvastatin calcium to be a low-molecular weight organogelator that forms organogels with a wide variety of alkyl alcohols. Size Price Stock; 1 mg USD 150 Ask For Quote & Lead Time or * Please select Quantity before adding items. Add a mixture of water and acetoni-trile (1:1) to about half the capacity of the flask, and shake by mechanical means for not less than 15 minutes to disintegrate the Tablet. Atorvastatin calcium,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting point as processes that generate amorphous forms. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol. The infrared absorption spectrum of atorvastatin calcium, Form-I, was obtained using a Nicolet FT-IR Impact 410 spectrophotometer equipped with deuterated triglycine sulfate detector, and using Omnic 5.1a software.The sample was contained in a pressed KBr pellet, with each spectrum being derived from 16 single scans over the range of 4000–400 cm –1 at a spectral resolution of 2 cm –1. Characterization of the pore structure of functionalized calcium carbonate tablets by terahertz time-domain spectroscopy and X-ray computed microtomography. atorvastatin calcium trihydrate: ChEBI ID CHEBI:2911: Definition A hydrate that is the trihydrate form of atorvastatin calcium. C181417-M6340-CHM22015, rev. 134523-03-8 - FQCKMBLVYCEXJB-MNSAWQCASA-L - Atorvastatin calcium [USAN:USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. … Atorvastatin is the most potent statin and has a long half-life. A new 43Ca NMR crystallographic approach which includes an exten 2019 PCCP HOT Articles Biological Activity; Purity & Documentation; References; Customer Review; Description: 2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Method and result: Sixty patients with hypercholesterolemia despite diet therapy were enrolled into the study. CAS No. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Atorvastatin (calcium salt) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. 2017;106:1586–95. 344423-98-9 - SHZPNDRIDUBNMH-NIJVSVLQSA-L - Atorvastatin calcium trihydrate - Similar structures search, synonyms, formulas, resource links, and other chemical information. Since atorvastatin trihydrate calcium is highly unstable ... Karttunen AP, Chakraborty M, Bawuah P, et al. 2015/830 and US OSHA HCS 2015 1.1 Product Code: 10493 Section 1. PS. Atorvastatin 6 (Figure 7) is a synthetic statin that contains an unusual penta-substituted pyrrole ring in place of the hexahydronaphthalene found in the early statins.The rationale for optimization employed a combination of insights from molecular modeling and hypothesis-based chemistry to define key structure–activity relationships. Background: Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin in the world. Request PDF | New Category for Active Pharmaceutical Ingredients, a Low Molecular Weight Organogelator: Crystal Structure of Atorvastatin Calcium and Its … The Atorvastatin calcium, with the CAS registry number 134523-03-8, is also known as CI 981. *Please select more than one item to compare Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. This chemical's molecular formula is C However, the sky soaring demand of ATC and an interesting structure of this drug directed the pharmaceutical scientist towards a high number of patents and many publications offering different crystalline forms as well as processes to generate alternative forms . Objectives: To quantify the dose-related effects of atorvastatin on blood lipids and withdrawals due to adverse effects (WDAE). Atorvastatin calcium is [R-(R*, R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1Hpyrrole-1-heptanoic acid, calcium salt (2:1)trihydrate. Zhou M, Shen L, Lin X, Hong Y, Feng Y. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol. Atorvastatin calcium C66H68CaF2N4O10 structure Molecular Formula C66H68CaF2N4O10 Average mass 1155.342 Da Density Boiling Point Flash Point Molar … Pediatric Patients Dyslipidemias Heterozygous Familial Hypercholesterolemia Oral Children 10–17 years of age: Initially, 10 mg once daily. J Pharm Sci. fer 1 Tablet to a volumetric flask of such capacity that when Atorvastatin Calcium filled to volume, a concentration of about 0.25 mg of chlorthal-idone per mL is obtained. Available as atorvastatin calcium; dosage expressed in terms of atorvastatin. 00 20180427. atorvastatin calcium contains an excipient [ an inactive ingredient in the form of calcium carbonate] and is equally effective in treating/reducing cholesterol and can be used instead of atorvastatin. ; Reduce the risk of MI and stroke in adult patients with type 2 diabetes without CHD, but with multiple risk factors (1.1). Surprisingly, in an extensive literature survey, atorvastatin calcium (ATC) is found … In case the solvent is water, the solid form is named hydrate. Dilute with water to volume, and mix. The crystal structure of atorvastatin calcium trihydrate (ACT) has been solved and refined using syn-chrotron X-ray powder diffraction data and optimized using density functional theory techniques. 1. Search results for Atorvastatin calcium at Sigma-Aldrich. They received atorvastatin 10 mg every other day before bedtime. Atorvastatin calcium,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting point Home Products Search Properties Search 中文版: Home > Dictionary > Information: Atorvastatin calcium Molecular formula : (C 33 H 34 FN 2 O 5) 2. We combine experimental and computational determination of 43Ca solid-state NMR parameters (chemical shift tensors, quadrupolar coupling tensors, and Euler angles) to constrain the structure of the local calcium–ligand coordination environment. The Atorvastatin Calcium Tablets Revision Bulletin supersedes the monograph that will be official in USP 41–NF 36. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Grapefruit and grapefruit juice may interact with atorvastatin and lead to potentially dangerous effects. Atorvastatin Calcium contains NLT 98.0% and NMT 115 100 0 102.0% of atorvastatin calcium (C 66H 68CaF 2N 4O 10), calcu- Diluent: N,N-dimethylformamide lated on the anhydrous •.and solvent-free basis. The formulations were evaluated for hardness, friability, weight variation, disintegration, and in vitro release study. 2-Hydroxy atorvastatin calcium salt Chemical Structure.
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