Use clotrimazole and betamethasone dipropionate cream for the prescribed treatment time, even if your symptoms get better. If you use clotrimazole and betamethasone dipropionate cream during pregnancy, use clotrimazole and betamethasone dipropionate cream on the smallest area of the skin and for the shortest time needed. In clinical trials common adverse reaction reported for clotrimazole and betamethasone dipropionate cream was paresthesia in 1.9% of patients. CLOTRIMAZOLE; BETAMETHASONE is a corticosteroid and antifungal cream.It treats ringworm and infections like jock itch and athlete's foot.It also helps reduce swelling, redness, and itching caused by these infections. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to using this medication. clotrimazole and betamethasone dipropionate cream, tell your healthcare provider about all your medical conditions, including if you: Tell your healthcare provider about all the medicines you take. No single-step or multiple-step resistance to clotrimazole has developed during successive passages of Trichophyton mentagrophytes. Avoid using other topical steroid medications on the areas you treat with betamethasone and clotrimazole, unless your doctor tells you to. The abnormalities observed included umbilical hernias, cephalocele, and cleft palates. Clinical studies of clotrimazole and betamethasone dipropionate cream did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. It is possible that topical administration of betamethasone dipropionate could result in sufficient systemic absorption to produce detectable quantities in human milk. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Do not use more than 45 grams of clotrimazole and betamethasone dipropionate cream in 1 week. Adverse reactions reported at a frequency less than 1% included rash, edema, and secondary infection. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids [see Warnings and Precautions (5.1)]. Tell your doctor if you are pregnant or plan to become pregnant. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Betamethasone is an inflammation-reducing corticosteroid that helps treat a range of skin conditions. Cataracts and glaucoma have been reported in postmarketing experience with the use of topical corticosteroid products, including topical betamethasone products [see Adverse Reactions (6.2)]. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It also is used to treat allergic or inflammatory conditions. In these same clinical studies, patients treated with clotrimazole and betamethasone dipropionate cream showed better clinical responses and mycological cure rates when compared with subjects treated with betamethasone dipropionate cream. In open-label trials, 17 of 43 (39.5%) evaluable pediatric subjects (aged 12 to 16 years old) using clotrimazole and betamethasone dipropionate cream for treatment of tinea pedis demonstrated adrenal suppression as determined by cosyntropin testing. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. They are, therefore also at greater risk of adrenal insufficiency during and/or after withdrawal of treatment. Identification Name Clotrimazole Accession Number DB00257 Description. Adverse events consistent with corticosteroid use have been observed in pediatric patients treated with clotrimazole and betamethasone dipropionate cream. If HPA axis suppression is documented, gradually withdraw the drug, reduce the frequency of application, or substitute with a less potent corticosteroid. Call your doctor if your symptoms do not improve after 1 week of using this medicine (or after 2 weeks if using the medicine on your feet). MedlinePlus Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects. Apply a thin layer of clotrimazole and betamethasone dipropionate cream to the affected skin area 2 times a day for 2 weeks. It is for external use only. It is not known if clotrimazole and betamethasone dipropionate cream will harm your unborn baby. Avoid getting betamethasone and clotrimazole topical in your eyes, mouth, or vagina. This may be done by using the adrenocorticotropic hormone (ACTH) stimulation test. Avoid use of clotrimazole and betamethasone dipropionate cream in the treatment of diaper dermatitis. Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids. Medicinal forms There can be variation in the licensing … Do not bandage, cover, or wrap the treated area unless your healthcare provider tells you to. Clotrimazole and betamethasone topical combination is used to treat fungus infections. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. However, clotrimazole dosed at 100 mg/kg/day was embryotoxic (increased resorptions), fetotoxic (reduced fetal weights), and maternally toxic (reduced body weight gain) to rats. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Active ingredients: clotrimazole and betamethasone dipropionate. Store clotrimazole and betamethasone dipropionate cream at room temperature between 68 to 77°F (20 to 25°C). Cushing’s syndrome and hyperglycemia may also occur due to the systemic effect of corticosteroids while on treatment. Avoid use of clotrimazole and betamethasone dipropionate cream in the diaper area, as diapers or plastic pants may constitute occlusive dressing. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane.This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Each gram of LOTRISONE cream contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a white to off-white, hydrophilic cream consisting of benzyl alcohol as a preservative, ceteareth-30, cetyl alcohol plus stearyl alcohol, … Store the lotion in an upright position. Cream, 1%/0.05% (base). Betamethasone and clotrimazole topical may also be used for purposes not listed in this medication guide. Oral clotrimazole doses of 25, 50, 100, and 200 mg/kg/day did not cause malformations in pregnant mice. The use of clotrimazole and betamethasone dipropionate cream under occlusion, such as in diaper dermatitis, is not recommended. Factors that predispose a patient to HPA axis suppression include the use of high-potency steroids, large treatment surface areas, prolonged use, use of occlusive dressing, altered skin barrier, liver failure, and young age. other antifungal medicines (such as itraconazole, ketoconazole, miconazole, posaconazole, or voriconazole). This drug is a broad spectrum antimycotic or antifungal agent. Skin penetration and systemic absorption of clotrimazole and betamethasone dipropionate following topical application of clotrimazole and betamethasone dipropionate cream has not been studied. NOT FOR OPTHALMIC, ORAL, OR INTRAVAGINAL USE. Studies in pregnant rats treated during organogenesis with intravaginal doses up to 100 mg/kg/day revealed no evidence of fetotoxicity due to clotrimazole exposure. General information about the safe and effective use of clotrimazole and betamethasone dipropionate cream. Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Do not use betamethasone and clotrimazole topical to treat any skin condition that has not been checked by your doctor. Use clotrimazole and betamethasone dipropionate cream as directed by the physician. Wash hands after each application. Ask your doctor about any risk. Clotrimazole and betamethasone dipropionate cream can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. "Clotrimazole Topical: MedlinePlus Drug Information". Three of the 8 normal subjects on whom clotrimazole and betamethasone dipropionate cream was applied exhibited low morning plasma cortisol levels during treatment. It is not for oral, ophthalmic, or intravaginal use. What should I avoid while using clotrimazole and betamethasone dipropionate cream? 99 ($4.99/Ounce) $8.99 $8.99 Parsippany, NJ 07054 USA, Clotrimazole (kloe trim' a zole) and Betamethasone Dipropionate (bay" ta meth' a sone dye proe' pee oh nate) Cream, 1%/0.05% (base).
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